Initial Chemical Events Caused by Carcinogenic Heterocyclic Amines and Molecular Design of Anti-tumor Agents

Carcinogenic Chemical Agents *

Cancer is a disease which has long been shrouded in mystery, but our knowledge of its intricacies has been extended in numerous directions by investigations carried on in all parts of the world by workers in many branches of science. Yet it remains true that in general we are not able to explain the origin of cancer, and the methods of treatment at present available are pitifully inadequate. Th...

Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes.

The N-hydroxylation of carcinogenic arylamines represents an initial step in their metabolic activation. Animal studies have shown that this reaction is catalyzed by the cytochrome P450 (P450) enzymes P450 1A1 and P450 1A2. In this study, utilizing enzymes expressed in Escherichia coli (and purified) or in human B-lymphoblastoid cells, the catalytic activities of recombinant human P450 1A1, P45...

Chemical Compounds as Carcinogenic Agents

A review of the progress made in the study of the carcinogenic properties of chemical compounds, incorporating literature published during the triennial period between the First and Second International Cancer Congresses, was presented to the Second International Congress in Brussels, in September 1936, and was subsequently reprinted with an addendum covering most of the literature published up...

Physical and chemical agents and carcinogenic risk.

Formation and human risk of carcinogenic heterocyclic amines formed from natural precursors in meat.

A group of heterocyclic amines that are mutagens and rodent carcinogens form when meat is cooked to medium and well-done states. The precursors of these compounds are natural meat components: creatinine, amino acids, and sugars. Defined model systems of dry-heated precursors mimic the amounts and proportions of heterocyclic amines found in meat. Results from model systems and cooking experiment...